Cytokine-dependent mechanisms in development of autoimmune thyroid disorders

Cover Page


This review of literature discusses impact of cytokine regulation in pathogenesis of autoimmune thyroiditis and Graves's disease.

About the authors

assistent kafedry endokrinologii i diabetologii; doktorant kafedry patofiziologii GOU VPO “Sibirskiy gosudarstvennyy meditsinskiy universitet Roszdrava”


  1. Белушкина Н.Н. Молекулярные основы патологии апоптоза / Н.Н. Белушкина, С.Е. Северин // Арх. патол. 2001. №1. С. 51–60.
  2. Дрометр Д.А. и др. Иммунологические аспекты дифференциальной диагностики синдрома гипертиреоза // Клин. и экспер. тиреоидол. 2007. Т. 3. №1. С. 18–23.
  3. Кандрор В.И. Механизмы развития болезни Грейвса и действия тиреоидных гормонов // Клин. и экспер. тиреоидол. 2008. Т. 4. №1. С. 26–34.
  4. Кандрор В.И. Эндокринология. М.: Практика, 1999.
  5. Лебедев К.А., Понякина И.Д. Иммунная недостаточность (выявление и лечение). М.: Медкнига, 2003.
  6. Пальцев М.А., Иванов А.А., Северин С.Е. Межклеточные взаимодействия. М.: Медицина, 2003.
  7. Сарвилина И.В. Междисциплинарные исследования в медицине / Сарвилина И.В., Каркищенко В.Н., Горшкова Ю.В. М.: Техносфера, 2007. С. 112–122.
  8. Фадеев В.В., Мельниченко Г.А., Герасимов Г.А. // Проб. эндокринол. 2001. Т. 47. №4. С. 7–13.
  9. Arpin C., Pihlgren M., Fraichard A. et al. Effects of T3Ra1 and T3Ra2 Gene Deletion on T and B lymphocyte Development // J. Immunol. 2000. V. 164. P. 152–160.
  10. Botella-Carretero J., Prados A., Manzano L. et al. The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal // Eur. J. Endocrinol. 2005. V. 153. P. 223–230.
  11. Bretz J.D., Baker J.R. Apoptosis and autoimmune thyroid disease: following a TRAIL to thyroid destruction? // Clin. Endocrinol. 2001. V. 55. N1. P. 1–11.
  12. Bretz J.D., Rymaszeweski M. TRAIL death pathway expression and induction in thyroid follicular cells // J. Biolog. Chemistr. 1999. V. 274. P. 23627–23632.
  13. Caturegli P., Mariotti S., Kuppers R.C. et al. Epitopes on thyroglobulin: a study of patients with thyroid disease // Autoimmunit. 1994. V. 18. P. 41-49.
  14. Fang Y., Braley-Mullen H. Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1-Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis // Endocrinol. 2008. V. 48. P. 3321–3329.
  15. Fang Y., Sharp G.C., Braley-Mullen H. Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis // Am. J. Pathol. 2008. V. 172. N6. P. 1591–1602.
  16. Giordano C., Stassi G., De Maria R. et al. Potential involvement of Fas and its ligand in the pathogenesis of Hashimotos thyroiditis // Science. 1997. V. 275. P. 960-963.
  17. Jiskra J., Antošová M., Límanová Z. et al. The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases // Clin. Experiment. Immunol. 2009. V. 156. P. 211–216.
  18. Kawakami A., Eguchi K., Matsuoka N. et al. Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro // Endocrinol. 1996. V. 137. P. 3163–3169.
  19. Kayagaki N., Yamaguchi N., Nakayama M. et al. Involvement of TNF-related apoptosis-inducing in human CD41 T-cell-mediated cytotoxicity // J. Immunol. 1999. V. 162. P. 2639–2647.
  20. Mariani S.M., Krammer P.H. Surface expression of TRAIL/Apo-ligand in activated mouse T and B cells // Eur. J. Immunol. 1998. V. 28. P. 1492–1498.
  21. Marino M., Chiovato L., Friedlander J.A. et al. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis // J. Clin. Endocrinol. Metab. 1999. V. 84. P. 2468–2474.
  22. Marino M., Zheng G., Chiovato L. et al. Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: a novel function in the control of thyroid hormone release // J. Biol. Chem. 2000. V. 275. P. 7125–7138.
  23. Mariotti S., Caturegli P., Piccolo P. et al. Antythyroid peroxidase antibodies in thyroid diseases // J. Clin. Edocrinol. Metab. 1990. V. 71. P. 661–669.
  24. Mascanfroni I., Montesinos M., Susperreguy S., Cervi et al. Control of dendritic cell maturation and function by triiodothyronine // FASEB J. 2008. V. 22. P. 1032–1042.
  25. McLachlan S.M., Rapoport B. The molecular biology of thyroid peroxidase: Cloning, expression, and role as autoantigen in autoimmune thyroid dis-ease // Endocr. Rev. 1992. V. 13. P. 192–206.
  26. Nakahara M., Nagayama Y., Saitoh O. et al. Expression of Immunoregulatory Molecules by Thyrocytes Protects Nonobese Diabetic-H2h4 Mice from Developing Autoimmune Thyroiditis // Endocrinol. 2009. V. 150. P. 1545–1551.
  27. Neves S.R., Ram P.T., Iyengar R. G-protein pathways // Science. 2002. V. 296. P. 1636–1639.
  28. Paolieri F., Salmaso C. Possible pathogenetic relevance of interleukin-1 beta in “destructive” organ-specific autoimmune disease (Hashimoto's thyroiditis) // Ann. N.Y. Acad. Sci. 1999. V. 22. N876. P. 221–228.
  29. Phenekos C. Th1 and Th2 serum cytokine profiles characterize patients with Hashimotos thyroiditis (Th1) and Graves disease (Th2) // Neuroimmunomodul. 2004. V. 11. P. 209–213.
  30. Poncin S., Lengele B., Colin I.M. et al. Differential Interactions between Th1/Th2, Th1/Th3, and Th2/Th3 Cytokines in the Regulation of Thyroperoxidase and Dual Oxidase Expression, and of Thyroglobulin Secretion in Thyrocytes in Vitro // Endocrinol. 2008. V. 149. P. 1534–1542.
  31. Solerte S.B. Defect of a subpopulation of natural killer immune cells in Graves disease and Hashimotos thyroiditis: normalizing effect of dehydroepi-androsterone sulfate // Eur. J. Endocrinol. 2005. V. 152. P. 703–712.
  32. Spitzweg C., Heufelder A.E. Update on the thyroid sodium iodide symporter: a novel thyroid antigen emerging on the horizon // Eur. J. Endocrinol. 1997. V. 137. P. 22–23.
  33. Tang H., Meroni P.L. The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells // Eur. J. Immunol. 1993. V. 23. P. 275–278.
  34. Vassart G., Dumont J.E. The thyrotropin receptor and the regulation of thyroid function and growth // Endocr. Rev. 1992. V. 13. P. 596–611.
  35. Volpe R. The pathology of thyroiditis // Hum. Pathol. 1978. V. 9. P. 429–438.
  36. Weetman A.P., Ajjan R.A. Cytokines and autoimmune thyroid diease // HOT THYROIDOLOGY ( 2002. N1.
  37. Wendling U. Expression of TRAIL receptors in human autoreactive and foreign antigen-specific T cells // Cell. Death. Differentiat. 2000. V. 7. P. 637–644.
  38. Yanagisawa J., Takahashi M., Kanki H. et al. The molecular interaction of Fas and FAP-1: a tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis // J. Biol. Chem. 1997. V. 272. P. 8539–8545.
  39. Zamai L. Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells // J. Exper. Med. 1998. V. 188. P. 2375–2380.



Abstract - 838

PDF (Russian) - 400




Copyright (c) 2010 ., ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies