Heart rate Variability and Efficiency Assessment of Graves' Disease Radioiodine Therapy

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Time of the transformation to the euthyroid condition after radioiodine therapy of Grave’s disease is individual and deviates from weeks to months, what requires frequent hormones control. The aim of this study was the assessment of possibility to use HRV parameters in dynamic control after the radioiodine therapy. 77 patients were examined with 114 fT4 measurement and HRV parameters recording (before radioiodine administration and in 1, 3, 6, 12 months after). From HRV parameters two were chosen as characterizing the closest correlation with fT4 and relatively independent from each other. The whole sample was divided into the teaching set (86 measurements) and the test set (28 measurements). The decision rule was found by support vector machine in the teaching set asf(HR,SDNN) = 0.995 lg(HR) – 0.104 lg(SDNN) – 1.703, where f is the indicator of the thyroid gland function, HR – heart rate during 5-minute ECG recording; SDNN – standard deviation of RR intervals; 0.995 , 0.104 and 1.703 – correcting coefficients. If f > 0, the thyrotoxicosis takes place in a patient. If f < 0 – there is no thyrotoxicosis. The analysis of diagnostic method precision in testing set gave the following results: diagnostic sensitivity was 71%, the diagnostic specificity 79%. This method can predict thyrotoxicosis elimination or relapse with high possibility. Its use can optimize thyroid function control and refuse from fixed time hormone measurement.

  1. Баевский Р.М. и др. Анализ вариабельности сердечного ритма при использовании различных электрокардиографических систем: Метод. реком. // Урал. кард. журн. 2002. № 1. C. 17–31.
  2. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability standards of measurement, physiological interpretation, and clinical use // Eur. Heart. J. 1996. V. 17. P. 354–381.
  3. La Rovere M.T., Bigger J.T.Jr., Marcus F.I. et al. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators // Lancet. 1998. V. 351. P. 478–484.
  4. Parati G., Mancia G., Di Rienzo M. et al. Cardiovascular variability is/is not an index of autonomic control of circulation // J. Appl. Physiol. 2006. V. 101. P. 676–682.
  5. Cerutti S., Goldberger A.L., Yamamoto Y. Recent Advances in Heart Rate Variability Signal Processing and Interpretation // Transact. Biomedic. Engineer. 2006. V. 53(1). P. 1–3.
  6. Barczynski M., Tabor S., Thor P. Evaluation of autonomic nervous function with heart rate variability analysis in patients with hyperthyroidism and during euthyroidism after pharmacologic and surgical treatment // Folia Med. Crakov. 1997. V. 38(3–4). P. 27–35
  7. Osman F. et al. Heart rate variability and turbulence in hyperthyroidism before, during and after treatment // Am. J. Cardiol. 2004. V. 15(4). P. 94. 465–469.
  8. Burggraaf J. et al. Sympatovagal imbalance in hyperthyroidism // Am. J. Physiol. Endocrinol. Metab. 2001. V. 281(1). P. E190–195.
  9. Cacciatory V. et al. Power spectral analysis of heart rate in hyperthyroidism // J. Clin. Endocrinol. Metab.1996. V. 81(8). P. 2828–2835.
  10. Chen J.L. et al. Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability // Clin. Endocrinol. (Oxf.). 2006. V. 64(6). P. 611–616.
  11. Hastie T., Tibshirani R., Friedman J. The elements of statistical learning: data mining, inference, and pediction Springer – Verlag, 2001. P. 214–216, 371–389.
  12. Реброва О.Ю. Статистический анализ медицинских данных. М., 2002. C. 247–251.


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