BRAF mutation in papillary thyroid microcarcinoma – additional marker of risk stratification

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Papillary thyroid microcarcinoma (PTMC) is heterogeneous group of tumor less than 1 cm in the diameter. The volume of surgical treatment stay unstable because unclear biological potential of PTMC.


The aim of our study was to assess the utility of BRAF gene mutation as preoperative additional marker of risk stratification.

Materials and methods

We include 44 patient who were operated in general surgery department Pavlov State Medical University from 2001 to 2013. In all 44 cases BRAF gene mutation was detected and compared with clinic-morphological features (multifocality, invasive growth, lymph node metastasis, recurrence) retrospectively


In our study the frequency of BRAF gene mutation was 68.2%. On multivariate regression analysis the presence of bilateral tumoural foci, lymph node metastasis and the presence of capsular invasion were significantly related to BRAF positive gene status.


Thus, appropriate volume for the BRAF positive PTMC is thyroidectomy with central compartment lymph node dissection.

About the authors

Dmitriy Yuriyevich Semyonov

First Pavlov State Medical University of St. Peterburg;
Federal Almazov Medical Research Centre, Saint-Petersburg


Russian Federation MD, PhD, Professor, Head of the General Surgery Chair of First Pavlov State Medical University of St. Peterburg, Head of the Endocrine Surgery department of Federal Almazov Medical Research Centre

Marina Evgenyevna Boriskova

First Pavlov State Medical University of St. Peterburg;
Federal Almazov Medical Research Centre, Saint-Petersburg


Russian Federation MD, PhD, Assistence professor of the general surgery chair of First Pavlov State Medical University of St. Peterburg, Chief Researcher of the Endocrine Surgery department in Federal Almazov Medical Research Centre

Mikhail Igorevich Zaraisky

First Pavlov State Medical University of St. Peterburg


Russian Federation MD, PhD, Professor of the clinical and laboratory diagnostic chair in First Pavlov State Medical University of St. Peterburg

Ul'yana Valentinovna Farafonova

First Pavlov State Medical University of St. Peterburg

Author for correspondence.

Russian Federation MD, PhD-student

Mikhail Andrianovich Bikov

First Pavlov State Medical University of St. Peterburg;
Federal Almazov Medical Research Centre, Saint-Petersburg


Russian Federation MD


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Copyright (c) 2014 Semyonov D.Y., Boriskova M.E., Zaraisky M.I., Farafonova U.V., Bikov M.A.

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