Vol 3, No 1 (2007)

Cover Page
Articles
VAK-2007: NOVYY PREDSEDATEL' I STARYE PROBLEMY. KTO KOGO?
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Abstract

Clinical and experimental thyroidology. 2007;3(1):2-7
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NEOBYChNYE REZUL'TATY IMMUNOLOGIChESKOGO ANALIZA I ROL' ENDOKRINOLOGA-KLINITsISTA
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Abstract

Подготовка публикации и перевод В.А. Вороненко
Clinical and experimental thyroidology. 2007;3(1):8-17
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Immunological Aspects of Differential Diagnostics of Hyperthyroidism
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Abstract

Clinical and experimental thyroidology. 2007;3(1):18-23
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NOVOSTI MIROVOY TIREOIDOLOGII
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Abstract

Перевод А.Е. Шведовой
Clinical and experimental thyroidology. 2007;3(1):24-31
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Diffential diagnostics and genealogical features of congential hypothyroidism in childrens
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Abstract

Congenital hypothyroidism (CH) being one of the most frequent thyroid disorder among children is etiologically heterogeneous. In this study various etiological forms of primary CH (ectopic thyroid gland, athyreosis, hypoplasia, dyshormonogenesis) were established by diagnostical algorithm. Complex approach with estimation of thyroid ultrasonography and scintigraphy (Tc-99m) data and the level of serum thyroglobulin allowed to differentiate ectopic thyroid gland and athyreosis. In the cases of eutopic gland additional examination was necessary. The most severe clinical symptoms and laboratory changes together with the lowest level of thyroglobulin were associated with agenesis. That could optimize the diagnostic approach. High occurrence of extrathyroidal congenital malformations was revealed in patients with ectopic gland and athyreosis and in their relatives. That could indicate that genetic factors influence on the forming of thyroidal dysgenesis.
Clinical and experimental thyroidology. 2007;3(1):32-37
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Morfology of Focal Lesious of the Thiroid Gland
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Abstract

To evaluate focal changes morphology the authors carried out a retrospective analysis in 297 patients who had earlier underwent surgery for different forms (multinodular/nodular) of goiter. In all cases preoperative US examination revealed thyroid nodules and focal lesions under 1 cm in the surrounding thyroid tissue. The results after US study taken part in the preoperative period were compared with histological examination data. Average patients age was 47.4 ± 11.9; median was 48 [17; 81]. For evaluation expression of a proliferation marker (Ki 67) and a development of a functional independence (TSH receptor) in the focuses of goiterous transformation at an immunnohistochemical study was formed a group of 25 cases (14 — focal hyperplasia and 11 — focal hypertrophy). 78.8% of focal changes were morphologically represented with goiterous or dystrophic origin (focuses of sclerosis, lymphoid infiltration and atrophy). Amongst them 56.6% were focal goiterous hypertrophy and hyperplasia. Evidently and moderately marked Ki 67 expression and negative expression of TSH-receptor in the focuses of goiterous hyperplasia proved the tendency to their growth with further transformation into colloid nodules and functional independence development.
Clinical and experimental thyroidology. 2007;3(1):38-42
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Focal Lesious of Thyroid Gland: efficacy of individual Iouide Prophylaxis
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Abstract

To determine the effectiveness of potassium iodide (200 mkg) to focal changes there was a clinical study taken. Only the patients with focal changes in thyroid were included. The main group was represented with 29 patients with normal thyroid volume and took potassium iodide. 27 patients were included into the group under control and underwent dynamic examination. The third group was consisted of 13 patients with thyroid goiter and getting potassium iodide (200 mkg). The examination of the patient with focal changes of thyroid was suspected to check thyroid status: thyroid ultrasound study, TSH serum level and antibodies to TPO at the beginning, in six months and in 12 months. Follow-up period for each patient was 12 months. Physiological iodide dose recommended with the aim of prophylaxis was apt to prevent the growth of the existent focal changes in thyroid tissue but not led to their full regression; prevent new focal changes in thyroid tissue; normalize thyroid volume in patients with thyroid goiter; do not influence on TSH levels and antybodies to TPO in patients with focal changes in thyroid tissue.
Clinical and experimental thyroidology. 2007;3(1):43-49
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The Condition of Thyroid and Fetoplacental Systems in Pregnant Women with Clinically Euthyroid Goiter
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Abstract

The aim is to study a condition of thyroid and fetoplacental systems at pregnant women with clinically euthyroid goiter. Materials and methods: 116 pregnant women have been included in the basic group with clinically euthyroid goiter. The control group was made by 60 pregnant women with physiologically proceeding pregnancy, not having anamnestic and the clinical data on diseases of the thyroid. Inspection included: definition of concentration thyroid-stimulating hormone (TSH) and free thyroxine (fT4) by a radio-immunologic method, sets “RIA-gnost” (France) and the maintenance of antibodies to thyroid peroxydase (anti-TPO) by a method hard phase immune-enzyme analysis; ultrasonic assessment of a thyroid with the help of device SONOACE 8800 “GAIA MT”; ultrasonic fetometry, placentography, measurement of amniotic fluid volume, doppler ultrasound examination of the blood flow, an estimation of a functional condition of a fetus on parameters of its biophysical profile (BP) and cardiotocography (CTG), carried out on device “Oxford Sonicaid Team S8000”. Results: At studying hormonal function thyroid systems at 25 pregnant (21.6%) with euthyroid goiter in the third trimester of pregnancy a level fT4 norms were lower and had values from 4.5 up to 6.9 ng/ml, therefore an average level fT4 at pregnant women of the basic group was authentically lower, than in control (8.26 ± 0.30 and 10.71 ± 0.52 ng/ml, accordingly). At the retrospective analysis it is established, that only at 5 of 116 (4.3%) pregnant women with a goiter were not complications pregnancy, at the others — 111 (95.7%) took place a combination various obstetric complications: an anemia — at 72 (62.0%), threat noncarrying of pregnancy — at 75 (64.6 %), an early toxicosis — at 45 (38.6%), a gestosis — at 47 (40.5%) which frequency authentically is higher, than in control group: 20.0%, 25.0%, 16.6%. 20.0%, accordingly, р < 0.05. Average Estimation CTG at patients of the basic group is authentically lower, than in control (7.2 ± 0.1; 7.9 ± 0.07 points accordingly, р < 0.05). The expressed infringement of biophysical activity of a fetus in the basic group proved to be true lower average estimation BP (8.3 ± 0.12 a point), than in control group (9.8 ± 0.13 a point). With a goiter the arrest of development of an intra-uterine fetus is diagnosed for pregnant women — at 19 (16.4%), infringement placentation — at 14 (12.1%), hypamnions - at 27 (23.3%), that is authentically more often, than in control group (9.5%; 3.3%; 3.3%, accordingly, р < 0.05). Conclusion: Thus, at pregnant women with euthyroid goiter decrease in thyroid function in second half of the pregnancy, resulting to development of hypothyroxinemia in 21,6 % of supervision is marked. Pregnancy at patients with euthyroid goiter frequently has the complicated character. At women with euthyroid goiter of change in fetoplacental system meet more often and in a significant greater measure that demands their duly revealing and correction.
Clinical and experimental thyroidology. 2007;3(1):50-54
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IV VSEROSSIYSKIY TIREOIDOLOGIChESKIY KONGRESS
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Abstract

Clinical and experimental thyroidology. 2007;3(1):55-56
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PO MATERIALAM V VSEROSSIYSKOGO KONGRESSA ENDOKRINOLOGOV
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Abstract

Clinical and experimental thyroidology. 2007;3(1):57-58
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EDINYE TREBOVANIYa K RUKOPISYaM, PREDSTAVLYaEMYM V ZhURNAL “KLINIChESKAYa I EKSPERIMENTAL'NAYa TIREOIDOLOGIYa”
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Abstract

Clinical and experimental thyroidology. 2007;3(1):59-60
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