Vol 12, No 4 (2016)

De Gustibus
Terrible force
Gerasimov G.A.

Positions that were previously held in public life by impartial expertise, are now heavily shaken. In the era of the Internet, Wikipedia and social networks, the masses moved from the natural skepticism to the opinion of experts to actively contradistinction their own ignorance with the amount of data accumulated by science and practice. The paradox is that campaigns against scientific knowledge are often led not only by ignoramuses, but by people who have all the possibilities for an adequate understanding of the issue.

Clinical and experimental thyroidology. 2016;12(4):4-10
Original Studies
Epidemiology and morphology of tumors of the thyroid gland in the Kabardino-Balkaria for the period 1990–2014
Tkhakakhov A.A.

Justification: cancer of a thyroid gland – the most frequent tumor of endocrine glands with a tendency of steady increase of incidence.

Aims: to study the structure, prevalence and trends in incidence, morphology of thyroid cancer among residents of the Kabardino-Balkaria for the period 1990–2014 years. To carry out the comparative analysis of incidence on gender and age of the population, geographical zones of the territory.

Material and methods. Annual reports the Oncological clinic of Ministry of health K-B, archival biopsies and postoperative material “Pathology Bureau”. Designed intense (coarse) and the standardized value for age and sex, the annual growth rate in the incidence of thyroid cancer using the world standard age distribution. Standardization carried out by the direct method.

Results. The rate of growth of the disease in the K-B exceed all-Russian especially impressive trend is observed among men. Intense (rough) values of the incidence is highest at age 50–59 years, standardized 70 years and older. K-B urban residents suffer most are the mountain population of the plains – most rural. Morphologically, the vast majority of carcinomas were the high-differentiated histological forms, more than half of the cases associated with a goiter.

Conclusions. The obtained results allow us to actively identify patients in the early stages, it is more efficient to carry out medical examinations and preventive measures, to plan a rational treatment strategy for patients.

Clinical and experimental thyroidology. 2016;12(4):11-15
Effects of selenium in patients with Graves’ disease treated with antithyroid drugs
Shabalina E.A., Fadeyev V.V.

In spite of previous conflicting results, an adjuvant role of selenium in the treatment of Graves’ disease (GD) hyperthyroidism has been proposed.

The aim of our study was to assess the effects of selenmethionine added to antithyroid drug therapy in patients with GD.

Methods. Twenty eight newly diagnosed hyperthyroid GD (mild or moderate severity) patients were randomly assigned to treatment during 12 months with: 1) thiomazole and levothyroxine + selenium or 2) thiomazole and levothyroxine. At base line and every 3 months the levels of TSH, fT4, fT3, TPO Ab, TRAbwere measured. For the thyroid tissue echogenicity assessment thyroid ultrasound was preformed. Follow-up period lasted 18 months (12 months of anthithyroid therapy, 6 month after withdrawal of antithyroid therapy, selenium was withdrawn after 15 months of therapy).

Results. There were no significant difference between the groups in biochemical restoration of hyperthyroidism, titers of TPO Ab and TRAb during the whole observational period. There were also no difference between the treatment groups in rate of relapse after the withdrawal of treatment.

Conclusions. Our study, failed to show an adjuvant role of selenium in the control of hyperthyroidism in patients with newly diagnosed GD.

Clinical and experimental thyroidology. 2016;12(4):16-30
Short messages
World Thyroidology News (#4 2016)
Manuylova Y.A., Moshenina S.E., Sviridonova M.A.

The article contains abstracts of actual modern international researches dedicated to management of various thyroid pathology and influence of accompanying states.

Clinical and experimental thyroidology. 2016;12(4):31-38
Editorial note
Review of European Thyroid Association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumours
Fadeyev V.V.

Hyperthyroidism is mainly due to autoimmune thyroid disorders or toxic goiter, and very rarely to the presence of thyrotropin (TSH)-secreting pituitary adenomas (TSHomas). These tumours are characterized by high levels of circulating free thyroid hormones (FT4 and FT3) in the presence of nonsuppressed serum TSH concentrations. Failure to correctly diagnose TSHomas may result in inappropriate thyroid ablation, which results in a significant increase of pituitary tumor mass. The diagnosis is mainly achieved by measuring TSH after T3 suppression and TRH stimulation tests. These dynamic tests, together with pituitary imaging and genetic testing are useful in distinguishing TSHomas from the syndromes of resistance to thyroid hormone action. The treatment of choice is surgery. In cases of surgical failure, somatostatin analogues have been found to be effective in normalizing TSH secretion in more than 90% of patients.

Clinical and experimental thyroidology. 2016;12(4):39-45

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